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Πλοήγηση ανά Θέμα "REGULATORY T-CELLS"

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    • Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: Lost and found 

      Rigopoulou, E. I.; Roggenbuck, D.; Smyk, D. S.; Liaskos, C.; Mytilinaiou, M. G.; Feist, E.; Conrad, K.; Bogdanos, D. P. (2012)
      Asialoglycoprotein receptor (ASGPR) has attracted the attention of liver immunologists for many years. This liver-specific lectin was found to be a major B and T cell autoantigenic target in patients with autoimmune liver ...

    • Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics 

      Gatselis, N. K.; Zachou, K.; Koukoulis, G. K.; Dalekos, G. N. (2015)
      Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology characterized by hypergammaglobulinemia, autoantibodies detection and interface hepatitis. Due to the absence of specific diagnostic ...

    • Diagnostic and clinical significance of anti-centromere antibodies in primary biliary cirrhosis 

      Liberal, R.; Grant, C. R.; Sakkas, L.; Bizzaro, N.; Bogdanos, D. P. (2013)
      Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver characterised by biochemical evidence of cholestasis, elevated alkaline phosphatase levels and the presence of the highly disease specific anti-mitochondrial ...

    • Familial primary biliary cirrhosis: Like mother, like daughter? 

      Smyk, D. S.; Rigopoulou, E. I.; Pares, A.; Mytilinaiou, M. G.; Invernizzi, P.; Bogdanos, D. P. (2012)
      The reasons underlying why autoimmune diseases overwhelmingly affect women more than men are not clear. Nor are the reasons why autoimmune disease is more prevalent in families. This review uses primary biliary cirrhosis ...

    • Foxp3 expression in human cancer cells 

      Karanikas, V.; Speletas, M.; Zamanakou, M.; Kalala, F.; Loules, G.; Kerenidi, T.; Barda, A. K.; Gourgoulianis, K. I.; Germenis, A. E. (2008)
      Objective: Transcription factor forkhead box protein 3 (Foxp3) specifically characterizes the thymically derived naturally occurring regulatory T cells (Tregs). Limited evidence indicates that it is also expressed, albeit ...

    • Foxp3 Expression in Liver Correlates with the Degree but Not the Cause of Inflammation 

      Speletas, M.; Argentou, N.; Germanidis, G.; Vasiliadis, T.; Mantzoukis, K.; Patsiaoura, K.; Nikolaidis, P.; Karanikas, V.; Ritis, K.; Germenis, A. E. (2011)
      Patients with chronic viral hepatitis display increased expression of Foxp3 in liver, suggesting that Tregs expansion contributes to persistent infection. The purpose of this study was to elucidate whether the expression ...

    • Potential Roles for Infectious Agents in the Pathophysiology of Primary Biliary Cirrhosis: What's New? 

      Smyk, D. S.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)
      Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease serologically characterized by the presence of high-titer antimitochondrial antibodies and, histologically by chronic nonsuppurative cholangitis ...

    • Review article: autoimmune hepatitis - current management and challenges 

      Zachou, K.; Muratori, P.; Koukoulis, G. K.; Granito, A.; Gatselis, N.; Fabbri, A.; Dalekos, G. N.; Muratori, L. (2013)
      BackgroundAutoimmune hepatitis (AIH) is a disease of unknown aetiology characterised by interface hepatitis, hypergammaglobulinaemia, circulating autoantibodies and a favourable response to immunosuppression. AimTo review ...

    • Sex Differences Associated with Primary Biliary Cirrhosis 

      Smyk, D. S.; Rigopoulou, E. I.; Pares, A.; Billinis, C.; Burroughs, A. K.; Muratori, L.; Invernizzi, P.; Bogdanos, D. P. (2012)
      Primary biliary cirrhosis (PBC) is a cholestatic liver disease of autoimmune origin, characterised by the destruction of small intrahepatic bile ducts. The disease has an unpredictable clinical course but may progress to ...

    • Urinary tract infection as a risk factor for autoimmune liver disease: From bench to bedside 

      Smyk, D. S.; Bogdanos, D. P.; Kriese, S.; Billinis, C.; Burroughs, A. K.; Rigopoulou, E. I. (2012)
      Autoimmune liver diseases include autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis. A variety of environmental and genetic risk factors have been associated with these conditions. ...

    • Vitamin D in autoimmune liver disease 

      Smyk, D. S.; Orfanidou, T.; Invernizzi, P.; Bogdanos, D. P.; Lenzi, M. (2013)
      The development of autoimmune disease is based on the interaction of genetic susceptibility and environmental causes. Environmental factors include infectious and noninfectious agents, with some of these factors being ...